Targeting TGF-β signal transduction for fibrosis and cancer therapy
I would like to share this publication, which is a comprehensive review investigating the role of TGF-β in immune regulation, tissue repair, and more. Overexpression of TGF-β can lead to immune dysfunction, fibrosis, and cancer, making therapeutics targeting TGF-β signaling promising strategies.
💡 In this in-depth review, they discuss:
1️⃣ The biological processes of TGF-β and its dual role in fibrosis and tumorigenesis 🧬
2️⃣ Clinical applications of TGF-β-targeting therapies 💊
3️⃣ The potential of TGF-β pathways as treatments for patients with fibrosis and cancer 🎯
4️⃣ Challenges in implementing TGF-β inhibition strategies due to systemic effects and the complexity of cancer and fibrosis development 🚧
TGF-β-targeted drugs have shown encouraging results in preclinical animal studies. Combining TGF-β-targeted therapy with other traditional therapies may lead to more effective treatment strategies.
Reference: Mol Cancer. 2022; 21: 104.
Published online 2022 Apr 23. doi: 10.1186/s12943-022-01569-x
Title: Targeting TGF-β signal transduction for fibrosis and cancer therapy
